Clinical leadership of an acute-care medical center chose to implement the nGage™ system along with a multi-modal hand hygiene improvement initiative on two medical surgical units. For this initiative, the team recognized increased hand hygiene solution dispensing volume, improved hand hygiene compliance, and reduced healthcare associated infection (HAI) rates. The team wanted to accurately quantify the initiative impact in terms of hand hygiene compliance, changes in HAIs and any financial benefits as a result of the identified changes. As a result of the initiative, the HAI rate on one unit decreased 13.1% and 18% on the other unit. These reductions equated to a variable cost savings of $100,190, a 120-day length of stay avoided and a return on investment of $1.42. The analysis demonstrated clear clinical and financial benefits of the hand hygiene improvement program.